5/5 - (14 votes) Insightful blog💯

I’ll walk you through everything endogenous depression, ranging from definition, symptoms, causes to treatment. Let’s dig in with Depression Open Talks.

Everybody has occasional low moods, but occasionally these moods persist. Clinical depression may develop when hopeless, gloomy, or numb feelings last for longer than two weeks.

With approximately 7% of the population experiencing it annually, depression is one of the most prevalent mental health diseases in the United States. Depression affects one in every six persons at some point in their lives. Substance misuse and depression are frequently linked, with many people using drugs or alcohol to try to alleviate their depressive symptoms.


Mental health professionals used to classify depression using two Latin terms: endogenous (from inside) and exogenous (from without). These terms were supposed to reflect if someone’s depression was caused by internal (genetic) or external (environmental) factors such as a traumatic event.

It’s traditionally believed that differentiation was vital and that each depression type required a separate approach. Depression, traditionally described as “endogenous,” is now classified as major depressive disorder (MDD). The current thinking is that whether MDD is endogenous or exogenous, the same sorts of treatment can be applied.


In contrast to depression brought on by environmental stressors, endogenous depression is brought on by a person’s genetic or biological causes. Let’s explore more about the definition of endogenous depression, its signs and symptoms, and available therapies.

It’s thought that some individuals have a predisposition from birth that renders them more prone to depressive episodes. Because it is genetically or biologically based, this type of depression is referred to as endogenous depression when it manifests. Compare that to exogenous depression, which is primarily brought on by events occurring in the environment surrounding a person.

Endogenous Depression is genetically based

For example, those who suffer from endogenous depression might not be aware of the reason for their abrupt onset of melancholy. They may have no explanation for the depression, yet they are unable to overcome it.

Exogenous depression, in contrast, is typically brought on by a very stressful incident and goes away once that situation or event has passed. Recovering after the end of a love relationship might serve as an illustration of this.

Symptoms of Endogenous Depression

Feelings of sadness or a lack of interest in once-enjoyed activities are the main characteristics of depression. Those who go through it frequently feel helpless and apathetic. While many people imagine someone depressed who is constantly sad and in tears, endogenous depression affects many people in seemingly normal ways. However, they might experience numbness and disinterest on the inside.

There are many distinct symptoms that depression can present with. Someone can lose interest in and lose joy in the things they formerly enjoyed. This condition is known as anhedonia, and it frequently comes with emotions like fear, guilt, hopelessness, and worthlessness. The person could feel worn out and unmotivated, not wanting to do the things they would usually like.

Endogenous Depression symptoms

Endogenous depression sufferers may experience unpredictable mood swings and difficulty concentrating. They frequently isolate themselves and don’t want to spend much time with friends or family. They might have trouble sleeping, either getting too much or too little sleep, and they might eat more or less than usual. Suicidal thoughts or sentiments can also accompany some forms of depression.

If you are suffering from endogenous depression, the world can appear gloomy and depressing to you as that is how you feel from within.

📚 Related Blog: Am I depressed or lazy? Fact-based Answer!

Causes of Endogenous Depression

Although endogenous depression lacks an external origin, it frequently has observable causes nonetheless. Simply said, personality traits like low self-esteem and a pessimistic outlook on life are among the most prevalent. These can make it more difficult to handle everyday stresses, which accumulate over time and result in depression.

Endogenous Depression Causes

Additional factors include genetics and way of life. Major depressive disorder and other mental diseases frequently run in families, according to research—which is still being studied—suggesting a genetic connection. Brain chemistry variations and depression are related.

Even if you can’t pinpoint a specific incident that started your endogenous depression, living in unhealthful, stressful, or unsafe situations frequently causes it. No matter if you are the victim of abuse or not, exposure to it is a common element of depression. Living in poverty significantly increases one’s risk of developing depression.

Treatment Options

If you’re suffering from depression, assistance is available. Although a treatment plan must be customized for each patient, it is typically effective in all except the most extreme cases. There are various popular methods of treating depression that has been proven to be successful. 


Psychotherapy is typically the first line of defense. Finding the best strategy for you may need some trial as there are many options. Cognitive behavioral therapy is one of the most popular and efficient treatments.

It aims to uncover negative and unhealthy thought patterns and train oneself to replace them with healthier ones. Other kinds are intended to aid in trauma healing or the development of constructive coping mechanisms. In fact, a lot of therapists combine different methods.


Antidepressants help a lot of patients with endogenous depression. These medications alter your brain chemistry subtly, which can make you feel more confident and content.

Antidepressants are generally safe for people in recovery because they don’t provide a buzz or high and are not habit-forming. Most people take them for at least six months, and it often takes two to four weeks for them to start working.

Antidepressants affect each person differently, so it’s crucial to inform your doctor if you experience any serious adverse effects or don’t benefit from the medication. You might be advised by your doctor to try a different kind.

Lifestyle Changes

Simple modifications to one’s lifestyle can assist, even though they rarely completely cure endogenous depression. Drug and alcohol use reduction or cessation is frequently a crucial component of depression treatment. A good diet, sufficient sleep, and regular exercise have also been proven to be beneficial.

Removing external stressors, such as securing a better career or a more secure housing arrangement, is a part of longer-term lifestyle adjustments. Creating a strong, encouraging social network is also useful.

Healing from Depression

There is assistance available if you or a family member are struggling with exogenous or endogenous depression. You can overcome depression and have a happier, healthier life by using a holistic strategy that combines therapy, medicine, and drug abuse treatment.


Although endogenous depression might be difficult to manage, you can go past your symptoms and lead a fulfilling life. Reaching out for support now can significantly improve how you feel and there are treatment options available.


Schimelpfening, N. (2022, July 21). Endogenous and Exogenous Depression: Symptoms, Causes, Treatment. Verywell Mind. Retrieved October 19, 2022, from https://www.verywellmind.com/what-is-endogenous-depression-1067283

What is Endogenous Depression? (2022, March 10). Choosing Therapy. Retrieved October 19, 2022, from https://www.choosingtherapy.com/endogenous-and-exogenous-depression/

What Is Endogenous Depression? – Definition, Symptoms & Treatment – Video & Lesson Transcript. (2021, October 14). Study.com. Retrieved October 19, 2022, from https://study.com/academy/lesson/what-is-endogenous-depression-definition-symptoms-treatment.html

Share if you like it